The accepted wisdom on this forum has been to use as much Sierra parts as possible, Sierra hubs even if you want some exotic engine (or Mazda MX-5). But if you feel confident enough that you'll find your way around, you can try building a GM-based roadster. Never done on this forum, AFAIK.
That said, AshG used a SAAB turbo lump to replace the small Pinto after one year of riding, he might give you some pointers.
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